Are General anesthetics neurotoxic?
نویسندگان
چکیده
منابع مشابه
Are volatile anesthetics neuroprotective or neurotoxic?
Volatile anesthetics are one class of the most commonly used drugs. However, the mechanisms for these drugs to induce anesthesia are not fully understood and have been under intensive investigation. Two other effects of these anesthetics on the central nervous system, volatile anesthetics-induced neuroprotection and neurotoxicity, currently are hot research fields. Although data from animal stu...
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GENERAL anesthetics are highly lipid soluble and can dissolve in every membrane, penetrate into organelles, and interact with numerous cellular constituents. Their actions have long been considered rapid and fully reversible, with the pharmacodynamic time course of anesthesia dictated solely by the pharmacokinetic profiles of anesthetic uptake and elimination. But recent laboratory data call fo...
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The term ‘‘anesthesia’’ was originally used by the ancient Greek surgeon Dioscorides and resurrected by Dr Oliver Wendell Holmes to describe the insensible state produced by inhalation of ether. The goals of general anesthesia include amnesia, unconsciousness (also termed hypnosis), and immobilization. By definition, general anesthetics reversibly produce all 3 of these therapeutic effects. Gen...
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Since William Morton successfully demonstrated the use of inhaled ether for surgical anesthesia in 1846, the development of new anesthetics and safe general anesthesia techniques have contributed greatly to the advancement of surgery and other invasive procedures. However, the underlying neurocellular mechanisms by which the state of general anesthesia is achieved are only just beginning to be ...
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Correa, Ana M. Gating kinetics of Shaker K1 channels are differentially modified by general anesthetics. Am. J. Physiol. 275 (Cell Physiol. 44): C1009–C1021, 1998.—The ShakerB K1 channel was used as a model voltage-gated channel to probe the interaction of volatile general anesthetics with gating mechanisms. The effects of three anesthetics, chloroform (CHCl3), isoflurane, and halothane, were s...
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ژورنال
عنوان ژورنال: International Archives of Medicine
سال: 2015
ISSN: 1755-7682
DOI: 10.3823/1652